Protein design

Generate backbones, then design sequences for them.

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Models in this category

RFdiffusion

Generates new protein backbones by diffusion — binders against a target, scaffolds around a motif, or proteins from scratch.

Takes

Target or template structure: PDB file or RCSB ID
Contig specification
Hotspot residues, optional

Returns

Backbone structure (PDB)

Per job

1–8 designs · 1–200 diffusion steps

Built · served by

Institute for Protein Design, University of Washington · NVIDIA BioNeMo NIM

Reference

Paper ↗

ProteinMPNN

Designs amino-acid sequences that are predicted to fold into a given backbone.